Papilloma virus genome


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Human Papillomavirus (HPV) anatomy

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papilloma virus genome

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Genome organization of human papillomavirus

HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting papillomavirus genome various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, papillomavirus genome adhesion and regulation of immune responses.

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High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle.

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