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Proteinele E6 si E7 produse de tipurile HPV cu risc crescut detin un rol esential in carcinogeneza fiind exprimate atat in leziunile cervicale pre-maligne cat si in cele avansate. Genele E6 si E7 se afla sub controlul proteinei codificata de gena E2.
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Tumor-associated macrophages TAMs can comprise a large proportion of tumor bulk. Clinical evidence also is pointing toward innate immune cells in cancer progression.
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