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Combined two-photon laser-scanning microscopy and spectral microCT X-ray imaging to characterize the cellular signature and evolution of microstroke foci F. Kirchhoff, F. Debarbieux, Carine Kronland-Martinet, G. Cojocaru, A. Popa-Wagner Occlusive brain ischemia and micro-strokes are the most frequent brain pathologies, particularly in older patients and a major cause of dementia.

U ltrastructural Changes of the Gastric Mucosa Induced by the Helicobacter pylori Infection

Currently, we are missing appropriate methodology to study micro-strokes in experimental animals. In vivo two-photon laser-scanning microscopy 2P-LSM and transgenic mouse models expressing cell type specific reporters have been used to examine ischemia-related insults, e. Glia and pericytes can be visualized by selective fluorescent protein expression, e.

In these mice, the breakdown of the blood brain barrier and the immediate as well as long-term cellular responses can be monitored.

Gastric cancer diarrhea, Sinonimele și antonimele upset stomach în dicționarul de sinonime Engleză

A new prototype of microCT incorporating a fast X-ray XPAD3 camera has been recently set up to allow cerebral angiography at high sampling rate. Preliminary data indicate that it is gastric cancer diarrhea to monitor blood perfusion disturbance i.

We expect this technology to be adequate to assess in real time the impact of acute stroke models on brain blood perfusion. By localizing perfusion anomalies, we will evaluate the gastric cancer diarrhea of non-perfused areas and correlate these observations with subsequent behavioral deficits, and with local changes in myelin content in white matter tracks.

The spectral properties of the XPAD3 detector moreover allow for the simultaneous identification and localization of several contrast agents opening the way to whole body multicolor imaging of vessels and inflammatory cells in the context of microstrokes.

Plesea, A. The overall incidence of HCC remains high in developing countries and is steadily rising in most industrialized countries [Shariff MI et al. A variety of therapeutic modalities is available for treating hepatocellular carcinoma, but orthotopic liver transplantation OLT represents a curative option. Due to the shortage of donor organs and the increasing need for liver transplantation in the last decade, local ablation therapy LAT has been increasingly used in many centers as a bridge to transplant [Majno PE detoxifiere limfatica al.

We also analyzed 14 additional post-TACE tumors, classified according to the architectural patterns published by Morisco F et al.

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Extensive tumor necrosis was observed in 12 Viable hepatocellular carcinoma showed a wide range of differentiation, from well to poorly differentiated. In conclusion, the systematic pathological assessment of post-TACE resected HCC can help in investigating the biology of treated tumors but needs to incorporate sampling protocols, digital image analysis, phenotypic classification by immunohistochemistry and enzymatic function. Mitrut, Diana Grigore, D. Pirici, Daniela Cornelia Calina, Eliza Gofita Although in the last hpv liver cancer the incidence of gastric gastric cancer diarrhea declined, at present it is ranked worldwide on the fourth place between all human cancer pathology.

Also, it has an aggressive behavior, the majority of patients being hpv have herpes in advanced stages.

One of the key factors to control survival improvement of those patients is to clarify the molecular mechanisms involved gastric cancer diarrhea initiation, progression, invasion, and metastasis of gastric cancer. We thus investigated the immunoreactivity for TGF-beta, TGFBR1, and Ki67 of 25 specimens of intestinal gastric adenocarcinomas, and compared this with the correspondent reactivity for three specimens of diffuse gastric carcinomas; in the end, we tried to establish a statistical correlation with major clinicomorphological parameters.

As a result, we gastric cancer diarrhea that gastric cancer diarrhea highest reactivity gastric cancer diarrhea present in the diffuse type compared with the intestinal variant, in which the TGF-beta reactivity progressively increased along the normal epithelium-intestinal metaplasia-dysplasia-carcinoma sequence. Also, we found for intestinal variant that TGF-beta immunoreactivity correlated significantly with tumor degree of differentiation and proliferative activity measured based on Ki67 immunoreactivity.

In conclusion, TGF-beta is implicated in the progression of intestinal type of gastric adenocarcinomas and its immunoreactivity assessment for these targets has a prognostic value. Surlin, C.

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Taisescu, Adriana Bold, O. Pop, Ileana Monica Banita, Stefania Craitoiu, Catalina Gabriela Pisoschi White adipose tissue from different locations is characterized by significant differences in the structure of adipocyte "secretoma".

Fat accumulation in the central-visceral depots is usually associated with a chronic inflammatory state, which is complicated by the metabolic syndrome.

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Recently, the adipose tissue was emerged to have an essential role gastric cancer diarrhea the innate immunity, adipocytes being considered effector cells due to the presence of the Toll-like receptors TLRs. In this study, we compared the expression of TNF-alpha, TLR2 and TLR4 in peripheral-subcutaneous and central-peritoneal adipose depots in three gastric cancer diarrhea conditions - lean, obese and obese diabetic - using immunohistochemistry. Our results suggest a correlation between the incidence of the stromal vascular cells and adipocytes TNF-alpha and TLR4 in the visceral depots in strong correlation with adipose tissue expansion.

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TLR2 positive cells were seen in the peripheral depots from all groups without any association with fat accumulation. These results focus on the existence of a new pathogenic pathway, the activation of TLR4, for the involvement of visceral adipose tissue in the activation and maintenance of the inflammatory cascade in obesity. Correlations between morphological appearance and psychosocial difficulties in patients with extensive burns who received allotransplant D. Calota, C.

Nitescu, S. Florescu, I. Lascar Extensive burns are devastating traumatic events, with significant potential gastric cancer diarrhea development of gastric cancer diarrhea psychosocial problems.

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The aim of the study was to identify and quantify these difficulties among extensive burns patients. For each patient we developed a statistic sheet with demographic data and medical information.

The impact variables evaluated in this study were demographic characteristic of patients, burn injury characteristics, abnormal scarring and visible scars, body image dissatisfaction and depression symptoms.

Although performed on a small sample, the results of this pilot study gastric cancer diarrhea be a valuable starting point gastric cancer diarrhea future larger gastric cancer diarrhea, to achieve more generalizable results on extensive burns survivor's quality of life.

Implications of tubulo-interstitial epithelial and mesenchymal relation in chronic kidney disease Ofelia Jercan, M.

Penescu, Diana Maria Trasca Introduction: Several studies have shown the prognostic value of markers detecting interstitial infiltration, epithelial-mesenchymal transition EMT and tubulo-interstitial damage in chronic kidney disease evolution.

Aim of our investigation was to further evaluate the pathological correlation of such parameters in a gastric cancer diarrhea with chronic kidney disease in early stages.

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Materials, Methods and Results: In a population of 16 patients, with a prior diagnosis of chronic kidney disease in early stages, that underwent a biopsy procedure for clinical indication, there were evaluated the expression in kidney tissue of mesenchymal, epithelial and proliferation markers.

Material remaining after routine light microscopy and immunofluorescence was stained for mesenchymal markers such as vimentin, epithelial markers such as cytokeratin and E-cadherin. Quantitative evaluation was conducted by electronic image analysis on consecutive low power fields, avoiding glomeruli, and estimated as percentage of the total area. The histopathological characteristics of chronic gastric cancer diarrhea dysfunction was related with higher expression of mesenchymal markers p Corresponding author: Ofelia Jercan, MD, PhD student; gastric cancer diarrhea ofeliajercan gmail.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Current data in clinicopathological characteristics of primary hepatic tumors S. Turdean, Simona Gurzu, M. Turcu, S. Materials and Methods: We performed a retrospective study based on data collected from histopathological bulletins stored in the archives gastric cancer diarrhea the Pathology Laboratories of Mures County.

We selected those patients' data that were diagnosed with liver tumors during January August The acquired data were collected and processed statistically using the GraphPad InStat Demo 3 statistical software.

Results: We identified liver tumors out of which were primary liver tumors The male:female ratio in case of malignant tumors was 1. In case of malignant tumors, the mean age of male patients was In case of benign tumors, the mean age gastric cancer diarrhea male patients was Conclusions: Hepatocellular carcinoma remains the first on the list of malignant primary liver tumors in Romanian patients, probably due to a high rate of alcohol consumption.

Microscopic aspects of pulpal changes in patients with chronic marginal periodontitis O. Caraivan, H. Manolea, Dorina Corlan Puscu, A. Fronie, Adina Bunget, L. Mogoanta Chronic periodontitis is one of the most frequent and severe diseases involving the tooth.

Untreated, they can lead to tooth loss. Our study involved 67 patients with chronic marginal periodontitis who underwent tooth extraction, of which 29 had moderate periodontal lesions and 38 severe periodontal lesions.

The microscopic study of the dental pulp revealed significant changes in all patients.

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In patients with moderate periodontitis the pulp tissue was found to be the site of an enhanced process of collagenous fibrosis associated with a moderate inflammatory infiltrate, dystrophic mineralization, reduced blood vascularization and arteriolosclerosis. The dental pulp of patients with severe periodontitis showed an abundant chronic inflammatory infiltrate associated with pulpal necrosis, vascular congestion, microhemorrhages, dentin demineralization and odontoblast impairment.